CHOP is an abbreviated name for a combination of different medications. CHOP is one of the most common combinations of medications used for non-Hodgkin lymphoma, or NHL.CHOP is used for some common types of aggressive as well as indolent NHL.It consists of four different medications: cyclophosphamide (Cytoxan), doxorubicin (Adriamycin), vincristine (Oncovin) and prednisone.